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Publications

Research

Publications

Some of our Consultants publications are listed below.

1. Abstracts

British Society Gastroenterology
http://www.bsg.org.uk/

  1. Lyth C, Brookes MJ, Green J, Brind A. The cost effectiveness of opioid analgesia for colonoscopy: a pilot study comparing pentazocine, pethidine, and nalbuphine hydrochloride. Gut. 2004;53(Suppl 3) A155.

  2. Sharma N, Salhan B, Brookes MJ, Cooper BT, Iqbal TH, Tselepis C. The expression of hepatic hepcidin and duodenal divalent metal transporter 1 are modified by ethanol and acetaldehyde. Gut. 2005;54(Suppl 2) A8.

  3. Sharma N, Brookes MJ, Cooper BT, Iqbal TH, Tselepis C. Small bowel iron absorption is inhibited by TNF-α. Gut. 2005;54(Suppl 2) A106.

  4. Brookes MJ, Douis H, Wilson PG. The incidence, clinical presentation and mortality associated with spontaneous bacterial peritonitis in a UK teaching hospital. Gut. 2005;54(Suppl 2) A38.

  5. Brookes MJ, Michell N, Wilson PG. Endoscopic retrograde cholangiopanctreatography training: the trainees perspective. A regional survey of gastroenterology trainees. Gut. 2005;54(Suppl 2) A72.

  6. Laftah A, Sharma N, Brookes MJ, Hughes S, Iqbal T, Tselepis C. A role for TNF-α in iron metabolism. Gut. 2005;54(Suppl 2) A5.

  7. Brookes MJ, Boult J, Hughes S, Sharma N, Ismail T, Hamilton E, Iqbal T, Tselepis C. A role for iron transporters in colorectal adenocarcinoma. Gut 2006;55(Suppl 2) A89.

  8. Boult J, Hughes S, Brookes MJ, Roberts P, Taniere P, Iqbal T, Tselepis C. A role for iron transporters in oesophageal adenocarcinoma. Gut 2006;55(Suppl 2) A88.

  9. Brookes MJ, Hughes S, Boult J, Sharma N, Turner F, Ismail T, Iqbal T, Tselepis C. Colonic iron loading reduces E-cadherin expression and enhances cellular proliferation. Gut 2006;55(Suppl 2) A87.

  10. Brookes MJ, Roberts K, Iqbal T, Tselepis C. Iron mediated cellular proliferation, migration and colony formation is dependent on adenomatous polyposis coli status in colorectal adenocarcinoma. Gut 2008;57(Suppl 1) A57.

  11. Farmer A, Brookes MJ, Wilson PG. ERCP training; What has changed in last 5 years? Gut 2008;57(Suppl 1) A

  12. Farmer A, Brookes MJ, Jones JIW, Wilson PG. Endoscopic ultrasound training: the trainees' perspective. Gut 2008;57(Suppl 1) A

  13. Brookes MJ, Roberts K, Iqbal T, Tselepis C. The regulation of cellular iron is defective in APC mutant colorectal carcinogenesis. Gut 2008;57(Suppl 1) A

  14. Roberts K, Spychal R, Brookes MJ, Strugala V, Dettmar PW, Johnstone M, Jolliffe IG, Tselepis C. Alginates inhibit the role of iron in an in vitro model of oesophageal adenocarcinoma. Gut 2008;57(Suppl 1) A

  15. R Desai, D Ward, M Brookes, C Tselepis, A Holt, T Iqbal. Serum hepcidin: a predictor of early graft dysfunction following orthotopic liver transplantation?Gut 2010;59:Suppl 1 A44

  16. M J Brookes, S Ford, G Caldwell, C Jones, T Iqbal, C Tselepis. Changes in the expression of cellular iron transport machinery occur in pre-neoplastic lesions within the colon in both sporadic and familial polyposis Gut 2010;59:Suppl 1 A17

  17. DA George, LL Hui, D Rattehalli, T Lovatt, I Perry, M Green, Robinson, MJ Brookes, JRF Walters. The role of near patient testing in patients with coeliac disease. Gut 2011.

  18. B Disney, E Fogden, P Sime, H Ellison, MJ Brookes Attitudes of UK Gastroenterology trainees to research and OOPE. Gut 2011.

Digestive Disease Week (AGA)
http://www.ddw.org/

  1. Brookes MJ, Sharma N, Hughes S, Cooper BT, Anderson G, Iqbal TH, Tselepis C. Overexpression of the iron transporter DMT-1 in colorectal carcinogenesis. Gastroenterology 2005;128(Suppl 2) A 365.

  2. Tselepis C, Laftah A, Brookes MJ, Sharma N, Hughes S, Iqbal TH. The role of tumour necrosis factor alpha in iron metabolism. Gastroenterology 2005;128(Suppl 2) A 366.

  3. Roberts K, Brookes MJ, Boult J, McKie AT, Iqbal T, Spychal R, Tselepis C. Expression of HCP-1 in Oesophageal Carcinogenesis. Gastroenterology 2007;132(Suppl 2) A303

  4. Brookes MJ, Boult J, Ismail T, Iqbal T, Tselepis C. A Role for Iron in Wnt Signalling and Human Colorectal Carcinogenesis. Gastroenterology 2007;132(Suppl 2)A632

  5. Roberts K, Brookes MJ, Boult J, Anderson GJ, Spychal R, Iqbal T, Tselepis C. A modulation of iron transport proteins in oeosphageal adenocarcinoma. Gastroenterology 2007;132(Suppl 2)A305

  6. Brookes MJ, Roberts K, Iqbal T, Tselepis C. Cellular iron drives in vitro proliferation and migration in colorectal adenocarcinoma. Gastroenterology 2008;134( Suppl 1)A37

  7. Roberts K, Ward DG, Brookes MJ, Naqvi M, Ismail T, Iqbal T, Tselepis C. Hepcidin expression relates to colorectal tumour stage. Gastroenterology 2008;134( Suppl 1)M1996

  8. Robert K, Brookes MJ, Spychal R, Iqbal T, Tselepis C. Increasing evidence for haem metabolism in oesophageal adenocarcinoma. Gastroenterology 2008;34( Suppl 1)M2015

  9. Roberts K, Spychal R, Brookes MJ, Strugala V, Dettmar PW, Johnstone M, Jolliffe IG, Tselepis C. Potential therapeutic role for alginates in the management of oesophageal adenocarcinoma. Gastroenterology 2008;134(Suppl 1)M2016

  10. Brookes MJ, Roberts K, Iqbal T, Tselepis C. Cellular iron regulation is defective in colorectal adenocarcinoma. Gastroenterology 2008;134(Suppl 1)S2029

United European Gastroenterology Week
https://www.ueg.eu/week/

  1. Brookes MJ, Cox M, Palejwala AP, Manjunatha SM, Hock YL, Ahmad I. Retrospective audit of 5 year's liver biopsies: percutaneous non-guided liver biopsy is as safe as guided liver biopsy. Endoscopy. 2003;35(Suppl 2) A163.

  2. Brookes MJ, Lewis KO, Iqbal TH. Anti-oxidant changes in active inflammatory bowel disease. Gut 2005; 54(Suppl 4) A234.

  3. Monika Maria Widlak 1 Edmond Atallah 1 Peter Strouhal 2Amanda Johnson 3 Matthew Brookes 1 Clinical value of SEHCAT SCAN in patients with chronic diarrhoea Gut 2013.

  4. Simon Whitehead 1 Ciro Morgese 2 Prita Banerjee 2 Ala Ali 2 Brian McKaig 2 Clare Ford 1 Jane French 3 Rousseau Gamma 1 Matthew James Brookes 2 The impact of fecal calprotectin results in clinical practice. Gut 2013.

  5. S. Whitehead C. Morgese B. McKaig P. Banerjee a. ali J. Waldron C. Ford R. Gamma M. Brookes. Faecal S100A12 is no better than calprotectin in the non-invasive assessment of inflammatory bowel disease. Gut 2013
  1. Roberts K, Brookes MJ, Boult J, McKie A, Spychal R, Iqbal T, Tselepis C. Uptake of haem iron in oesophageal adenocarcinoma; possible mechanism of carcinogenesis. Br J Surg 2007, 94 (suppl 2):89

  2. Roberts K, Brookes MJ, Boult J, Anderson G, Spychal R, Iqbal T, Tselepis C. A role for iron in oesophageal adenocarcinoma. Br J Surg 2007, 94 (suppl 2):89

  3. Brookes MJ, Boult J, Joy H, Iqbal T, Ismail T, Tselepis C. The regulation of ß-catenin/TCF signalling by inorganic and organic iron. Colorectal Disease 2007, 9 (Suppl1):63.
2. Papers
  1. Brookes MJ, Gould TH. Cerebral salt wasting syndrome in meningoencephalitis: a case report. J Neurol Neurosurg Psychiatry. 2003;74(2):277.

  2. Brookes MJ, Brind AM. Coin ingestion, an unexpected finding at Colonoscopy: case report. Medscape General Medicine. 2003;5(1).

  3. Brookes MJ. Letter in response to The Management of Cirrhotic Ascites. Medscape General Medicine. 2003;4(4).

  4. Brookes MJ, Manjunatha S, Allen C, Cox M. Malignant potential in a Brunner's gland hamartoma: a case report. Postgrad Med J. 2003;79:416-417.

  5. Brookes MJ, Green JRB. Maintenance in Crohn's disease – current and emerging therapeutic options. Drugs. 2004;64(10):1069-1089.

  6. Brookes MJ, Sharma N, Tselepis C, Iqbal TH. Serum pro-hepcidin: an active metabolite or inactive precusor? Gut. 2005 Jan;54(1):169-70.

  7. Sharma N, Laftah A, Brookes MJ, Cooper BT, Tselepis C, Iqbal TH. A role for tumour necrosis factor alpha in human small bowel iron transport. Biochem J. 2005;390:437-46.

  8. Laftah A, Brookes MJ, Sharma N, Hughes S, Tselepis C, Iqbal T. Tumour necrosis factor alpha causes hypoferraemia and reduced intestinal iron absorption in mice. Biochem J. 2006;397(1):61-7.

  9. Brookes MJ, Hughes S, Turner FE, Reynolds G, Sharma N, Ismail T, Berx G, McKie AT, Hotchin N, Anderson GJ, Iqbal T, Tselepis C. Modulation of iron transport proteins in human colorectal carcinogenesis. Gut. 2006;55(10):1449-60.

  10. Brookes MJ, Field M, Dawkins DM, Gearty J, Wilson P. Massive primary hepatic tuberculoma mimicking hepatocellular carcinoma in an immunocompetent host. MedGenMed. 2006;18;8(3).

  11. Brookes MJ, Iqbal T, Cooper BT. Hypertension and fatty liver: guilty by association? J Hum Hypertens. 2007; 21(4):264-70.

  12. Brookes MJ, Boult J, Roberts K, Cooper BT, Hotchin NA, Matthews G, Iqbal T, Tselepis C. A role for iron in Wnt signalling. Oncogene. 2007 Aug 13; [Epub ahead of print].

  13. Brookes MJ. Digestive diseases week 2007: a conference report. IBDigest. Available online at: http://www.oysterhc.co.uk/ibdigest.

  14. Roberts K, Boult J, Brookes MJ, Hughes S, Bury J, Cross SS, Anderson GJ, Spychal R, Iqbal T, Tselepis C. Over expression of cellular iron import proteins is associated with malignant progression of esophageal adenocarcinoma. Clin Can Res. 2008;14(2): 379-87.

  15. Ward DG, Brookes MJ, Roberts K, Naqvi M, Joy H, Martin Ashley, Ismail T, Iqbal T, Tselepis C. Increased hepcidin expression in colorectal adenocarcinoma. World Journal of Gastroenterology 2008;14(9):1339-45.

  16. Brookes MJ, Iqbal TH, Cooper BT. Hypertension and steatosis hepatis. Current hypertension reports 2008; accepted.

  17. Simpson JA, Tselepis C, Iqbal T, Acheson AG, Brookes MJ. Br J Surg. 2010 Feb;97(2):298-9. Randomized clinical trial of preoperative intravenous iron sucrose to reduce blood transfusion in anaemic patients after colorectal cancer surgery (Br J Surg 2009; 96: 1122-1128).

  18. Simpson JAD, Ng SL, Brookes MJ, Acheson AG, (2010) Single Dose Preoperative Administration of Intravenous Iron Corrects Iron Deficiency Anaemia in Colorectal Cancer. J Blood Disord Transfus 1:101.

  19. Chauhan A, Bosanko N, Brookes M, Moss M, Wilson P. 15 years of liver abscesses from a UK centre. J R Coll Physicians Edinb. 2011 Mar;41(1):13-7.

  20. Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.Mells GF, Floyd JA, Morley KI, Cordell HJ, Franklin CS, Shin SY, Heneghan MA, Neuberger JM, Donaldson PT, Day DB, Ducker SJ, Muriithi AW, Wheater EF, Hammond CJ, Dawwas MF; UK PBC Consortium; Wellcome Trust Case Control Consortium 3, Jones DE, Peltonen L, Alexander GJ, Sandford RN, Anderson CA.Nat Genet. 2011 Mar 13;43(4):329-32. Member of contributing PBC consortium.

  21. Acheson A, Brookes MJ and Spahn D. Effects of allogeneic red blood cell transfusions on clinical outcomes in patients undergoing colorectal cancer surgery – Systematic review and meta-analysis. Ann Surg. 2012 Aug;256(2):235-44.

  22. Dowswell G, Ryan A, Taylor A, Daley A, Freemantle N, Brookes M, Jones J, Haslop R, Grimmett C, Cheng KK, Wilson S; Colorectal Cancer Prevention Group. Designing an intervention to help people with colorectal adenomas reduce their intake of red and processed meat and increase their levels of physical activity: a qualitative study. BMC Cancer. 2012 Jun 18;12:255.

  23. Chauhan A, Perry I, Veitch A, Li P, Rattehalli D, Brookes MJ. Gastropericardial fistula: a potential role for conservative treatment. Eur J Gastroenterol Hepatol. 2012 Nov;24(11):1341-3.

  24. Chauhan A, Perry I, Veitch A, Li P, Rattehalli D, Brookes MJ. Gastre-pericardial fistulae: is there a role for conservative management. Eur Journal of Gastroenterology Accepted.

  25. Sorina Radulescu 1, Matthew J Brookes 2, Pedro Salgueiro 1, Rachel A Ridgway 1, Ewan McGhee 1, Kurt Anderson1, Samuel Ford 2, Daniel Stone 2,Tariq H Iqbal 2 , Chris Tselepis 2# and Owen J Sansom 1# Luminal iron levels govern intestinal tumourigenesis following Apc loss in vivo. Cell Rep. 2012 Aug 30;2(2):270-82.

  26. Keeler BD, Krell J, Acheson AG, Brookes MJ, Stebbing J, Frampton AE. Is there a role for intravenous iron therapy in patients undergoing colorectal cancer resection? Expert Rev Anticancer Ther. 2012 Nov;12(11):1407-12.

  27. Liu JZ, Almarri MA, Gaffney DJ, Mells GF, Jostins L, Cordell HJ, Ducker SJ, Day DB, Heneghan MA, Neuberger JM, Donaldson PT, Bathgate AJ, Burroughs A, Davies MH, Jones DE, Alexander GJ, Barrett JC, Sandford RN, Anderson CA; UK Primary Biliary Cirrhosis (PBC) Consortium; Wellcome Trust Case Control Consortium 3. Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis. Nat Genet. 2012 Oct;44(10):1137-41

  28. Carbone M, Mells GF, Pells G, Dawwas MF, Newton JL, Heneghan MA, Neuberger JM, Day DB, Ducker SJ; UK PBC Consortium, et al. Sex and age are determinants of the clinical phenotype of primary biliary cirrhosis and response to ursodeoxycholic acid. Gastroenterology. 2013 Mar;144(3):560-569.

  29. Whitehead SJ, French J, Brookes MJ, Ford C, Gama R. Between-assay variability of faecal calprotectin enzyme-linked immunosorbent assay kits. Ann Clin Biochem. 2013 Jan;50(Pt 1):53-61.

  30. Pells G, Mells GF, Carbone M, Newton JL, UK PBC Consortium et al. The impact of liver transplantation on the phenotype of primary biliary cirrhosis patients in the UK-PBC cohort. J Hepatol. 2013 Jul;59(1):67-73.

  31. Keeler BD, Brookes MJ. Iron chelation: a potential therapeutic strategy in oesophageal cancer. Br J Pharmacol. 2013 Mar;168(6):1313-5.

  32. Padmanabhan H, Iqbal T and Brookes MJ. Iron & colorectal cancer in 2013; evidence from in vitro and animal studies. Nutr Reviews. Under review 2014.

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